This was a game which could have ultimately decided Tranmere’s Football League status.
Tranmere came out a new side off the back of poor performances and dominated the game for the opening twenty-five minutes.
Oxford then started to attack back and came close before half-time through Danny Hylton.
Just six minutes after the interval, Kemar Roofe headed home from Sam Long’s cross.
Just two minutes later, Alex MacDonald set up Danny Rose who slotted the ball into the net to double Oxford’s lead.
The visitors wrapped the game up on sixty-eight minutes when Kemar Roofe tucked away his second of the game.
The large exit of Tranmere fans summed up the mood around Prenton Park.
Substitutes Marc Laird and Jason Koumas came close late on but a 0-3 defeat leaves Tranmere rooted to the bottom of the Football League two points from safety with two games to go.
On Sunday it was announced that Micky Adams had left the club by mutual consent.