Tranmere came into this game after beating Cambridge away 2-1 to ease the pressure slightly on Micky Adams and move out of the relegation zone. Burton however, would be looking to strengthen their hold at the top of League Two.
Burton started the game the better of the two sides as they dominated possession and the midfield of the pitch.
Damien McCrory put the Brewers in front after eighteen minutes with a left footed strike.
Just four minutes later, former Tranmere striker Lucas Akins doubled Burton’s lead with a tap in after poor defending.
Kayode Odejayi then scored a twenty-five yard screamer ten minutes before half-time which gave Tranmere some confidence going forward for the remainder of the half.
Tranmere then had the chance to equalise on fifty-seven minutes from the penalty spot when Odejayi was bundled over but Max Power’s effort was well-saved by Burton Keeper Jon McLaughlin.
Burton then went on the attack again and Nasser El Khayati restored Burton’s two goal lead.
Adam Dugdale then compounded the defeat for Tranmere when he hooked the ball into his own net in the eighty-ninth minute.
The exodus of Tranmere fans after Burton’s fourth summed up the mood around Prenton Park.
The result keeps Burton at the top of League Two and five points clear of Shrewsbury Town in second. Tranmere stay twenty-second with only goal difference separating them and Cheltenham and Hartlepool closing the gap to just one point.