Tranmere have been struggling near the bottom of the table recently whilst opponents Cambridge have been milling around near the top half after some impressive performances.
The best chance of the first part of the game was a Cambridge header which was cleared off the line.
Tranmere then broke the deadlock in the third minute of added time in the first half. Good work on the left wing from Jennison Myrie Williams allowed him to cross before the ball was cleared to the edge of the box for Max Power to strike into the bottom corner.
Substitute Sullay Kaikai had only been on the pitch for eight minutes before he pulled United level. The Crystal Palace loanee made a pacy run through the Tranmere defence before putting the ball past Owain Fon Williams.
Dan Gardner then put Tranmere back in the lead on sixty eight minutes after clever work on the left again by Myrie Williams.
Owain Fon Williams was then called into duty to protect the lead when he saved well from Tom Elliott.
Steve Jennings then received his second yellow card of the game for Tranmere.
Tranmere managed to hold on for the rest of the game and the St Patrick’s Day result allowed the fans to drink in celebration rather than to drown their sorrows.
Tranmere moved out of the relegation zone on goal difference and Cambridge dropped down to eighteenth place.